pathophysiology of ischemia/reperfusion-induced myocardial injury: what we have learned from preconditioning and postconditioning?
نویسندگان
چکیده
organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. the pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. in this review, we discuss basic mechanisms involved in the pathophysiology of ischemia/reperfusion injury. moreover, the pharmacology of preconditioning and postconditioning is delineated.
منابع مشابه
Pathophysiology of Ischemia/Reperfusion-induced Myocardial Injury: What We Have Learned From Preconditioning and Postconditioning?
Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechan...
متن کاملPathophysiology of Ischemia/Reperfusion-induced Myocardial Injury: What We Have Learned from Preconditioning and Postconditioning?
Organ damage after reperfusion of previously viable ischemic tissues is defined as ischemia/reperfusion injury. The pathophysiology of ischemia/reperfusion injury involves cellular effect of ischemia, reactive oxygen species and inflammatory cascade. Protection against ischemia/reperfusion injury may be achieved by preconditioning or postconditioning. In this review, we discuss basic mechanisms...
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متن کاملPathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures.
Heart diseases due to myocardial ischemia, such as myocardial infarction or ischemic heart failure, are major causes of death in developed countries, and their number is unfortunately still growing. Preliminary exploration into the pathophysiology of ischemia-reperfusion injury, together with the accumulation of clinical evidence, led to the discovery of ischemic preconditioning, which has been...
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عنوان ژورنال:
iranian journal of pharmacology and therapeuticsجلد ۷، شماره ۱، صفحات ۱۱۵-۰
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